5-methyltetrahydrofolate (5-MTHF) is the active form of folate, a vitamin that is essential for DNA synthesis, repair, and methylation. The human body cannot produce folate on its own, so it must be obtained through diet or supplementation.
5-MTHF is important because it is the form of folate that can cross the blood-brain barrier and enter the central nervous system. This makes it crucial for brain function, including mood regulation, memory, and cognitive performance.
Additionally, 5-MTHF is used by the body to convert homocysteine to methionine, an amino acid that is important for protein synthesis and other metabolic processes. Elevated homocysteine levels have been linked to increased risk of cardiovascular disease, so ensuring adequate levels of 5-MTHF may help lower this risk.
Some individuals may have genetic variations that make it difficult for their bodies to convert folic acid (the synthetic form of folate found in many supplements and fortified foods) to 5-MTHF. In these cases, supplementing directly with 5-MTHF may be more effective for achieving optimal folate levels.
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