Cyclins are a family of proteins that regulate the progression of the cell cycle. They are distinguished by their periodicity, with each type of cyclin being present at specific stages of the cell cycle. Cyclins bind to and activate specific cyclin-dependent kinases (CDKs), which then phosphorylate target proteins, leading to the initiation of cellular events such as DNA replication, chromosome segregation, and cytokinesis. The name "cyclin" comes from the fact that their levels oscillate with the cell cycle, reaching a peak at specific points before dropping off sharply. Different types of cyclins are responsible for regulating different stages of the cell cycle, such as G1, S, G2, and M phase. Cyclins are critical for maintaining the normal progression of the cell cycle and for preventing abnormal cell division, which can lead to cancer and other diseases.
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