What is mdni?

MDNI (Metabolic Dysfunction-Associated Steatotic Liver Disease, formerly known as NAFLD)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD), is a chronic liver disease characterized by the accumulation of fat in the liver in people who consume little or no alcohol. It is strongly associated with metabolic risk factors. It's a broad term that encompasses a spectrum of liver conditions, ranging from simple steatosis (fatty liver) to non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and liver failure.

Key aspects of MDNI:

• Definition and Diagnosis: MDNI is defined by the presence of hepatic steatosis (fat accumulation in the liver) and at least one cardiometabolic risk factor. These risk factors include:
  • Obesity or overweight
  • Type 2 diabetes
  • High blood pressure (hypertension)
  • Dyslipidemia (abnormal blood lipids, such as high triglycerides or low HDL cholesterol).
• Causes and Risk Factors: The exact cause of MDNI is not fully understood, but it is strongly linked to insulin resistance, obesity, and other metabolic abnormalities.
• Progression: MDNI can progress from simple steatosis to <a href="https://www.wikiwhat.page/kavramlar/Non-Alcoholic%20Steatohepatitis">Non-Alcoholic Steatohepatitis</a> (NASH), which involves inflammation and liver cell damage. Over time, NASH can lead to fibrosis (scarring of the liver) and eventually <a href="https://www.wikiwhat.page/kavramlar/Cirrhosis">Cirrhosis</a>, liver failure, and even liver cancer.
• Symptoms: Many people with MDNI have no symptoms, especially in the early stages. As the disease progresses, symptoms may include fatigue, abdominal pain, and an enlarged liver.
• Diagnosis: MDNI is often diagnosed through blood tests that reveal elevated liver enzymes, such as ALT and AST. Imaging tests, such as ultrasound, CT scans, or MRI, can also be used to detect fat in the liver. A liver biopsy may be necessary to confirm the diagnosis and assess the severity of the liver damage.
• Treatment: The primary treatment for MDNI involves lifestyle modifications, such as weight loss, a healthy diet, and regular exercise. Medications may be used to manage associated conditions like diabetes and high cholesterol. In severe cases, a liver transplant may be necessary.
• Prevention: <a href="https://www.wikiwhat.page/kavramlar/Prevention">Prevention</a> focuses on maintaining a healthy weight, eating a balanced diet, and engaging in regular physical activity. Controlling diabetes, high blood pressure, and high cholesterol is also important.