What is norfentanyl?

Norfentanyl is a metabolite of fentanyl, which is a potent synthetic opioid pain medication. It is produced in the body when fentanyl is metabolized by enzymes in the liver. Norfentanyl is an active metabolite and can contribute to the overall effects of fentanyl when it accumulates in the body.

Norfentanyl has a similar pharmacological profile to fentanyl, but its potency is lower. It binds to the same mu opioid receptors in the brain and spinal cord, leading to pain relief and other opioid effects. However, norfentanyl is less potent than fentanyl and is believed to have a shorter duration of action.

Due to its pharmacological activity, norfentanyl can contribute to the overall effects of fentanyl and may be detected in toxicological analyses of individuals who have used fentanyl. It is important for healthcare providers to be aware of the presence of norfentanyl when interpreting drug test results and managing patients who have been exposed to fentanyl.