What is occludin?

Occludin is a protein that plays a key role in the formation and maintenance of tight junctions, which are specialized connections between epithelial cells that regulate the movement of ions and molecules across cell layers. It is a transmembrane protein that helps to seal the intercellular space and prevent the passage of unwanted substances.

Occludin is found in high levels in epithelial and endothelial cells, where it contributes to the integrity of the barrier function of these tissues. Disruption of occludin expression or function has been linked to a variety of diseases, including inflammatory bowel disease, cancer, and neurological disorders.

Studies have shown that occludin interacts with other tight junction proteins, such as claudins and junctional adhesion molecules, to form a tight and selective barrier. Research on occludin is ongoing, as scientists continue to investigate its role in health and disease and explore potential therapeutic targets for conditions involving disrupted barrier function.