What is enclomiphene?

Enclomiphene is a selective estrogen receptor modulator (SERM) that is used to treat secondary hypogonadism in men. It is one of two isomers of clomiphene, the other being zuclomiphene. While clomiphene is a mixture of both isomers, enclomiphene contains only the enclomiphene isomer.

Here's some key information:

• Mechanism of Action: Enclomiphene blocks estrogen receptors in the hypothalamus. This action reduces negative feedback on the hypothalamus, leading to increased secretion of gonadotropin-releasing hormone (GnRH). GnRH stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH then stimulate the testes to produce testosterone and sperm. See: Mechanism%20of%20Action
• Use: The primary use is for treating secondary hypogonadism. This condition occurs when the testes are healthy but not receiving enough stimulation from the pituitary gland due to hypothalamic or pituitary dysfunction. Enclomiphene helps to increase testosterone levels and sperm production in these cases. See: Use
• Advantages over Clomiphene: Some argue that enclomiphene offers advantages over clomiphene, such as a potentially improved side effect profile. This is because zuclomiphene, the other isomer in clomiphene, has a longer half-life and is thought to contribute to some of the adverse effects associated with clomiphene.
• Administration: Enclomiphene is typically administered orally.
• Side Effects: Common side effects can include hot flashes, mood changes, and visual disturbances. See: Side%20Effects
• Clinical Trials: Enclomiphene has been the subject of several clinical trials to assess its efficacy and safety in treating hypogonadism.

It is important to note that enclomiphene should only be used under the supervision of a qualified healthcare professional.