What is enclomiphene?

Enclomiphene is a selective estrogen receptor modulator (SERM) that is often used in the treatment of male hypogonadism and fertility issues. It is one of the isomers of clomiphene citrate, which is traditionally used as a fertility drug for women. Enclomiphene works by blocking estrogen receptors in the hypothalamus, leading to an increase in the release of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the pituitary gland to produce more luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which can enhance the production of testosterone and sperm in men.

Enclomiphene is sometimes used as an alternative to testosterone replacement therapy (TRT) because it can stimulate the body's own production of testosterone without negatively impacting fertility. This makes it a particularly attractive option for males who are looking to boost testosterone levels while maintaining or improving fertility status.

It’s important to note that as of now, enclomiphene is not approved by regulatory agencies like the FDA specifically for treating low testosterone levels or other conditions in men, and its use is often considered off-label. Research and clinical trials are ongoing to better understand its efficacy and safety profile.

Potential side effects of enclomiphene treatment may include headaches, visual disturbances, mood swings, and gastrointestinal issues. As with any medication, its use should be under the guidance of a healthcare professional.