What is pronebone?

Pronebone: A Bioactive Bone Graft Substitute

Pronebone is a synthetic bone graft substitute used in orthopedic and dental surgeries to facilitate bone regeneration. It is designed to mimic the structure and properties of natural bone, providing a scaffold for new bone growth.

Here's a breakdown of key aspects:

• Composition: Pronebone is primarily composed of <a href="https://www.wikiwhat.page/kavramlar/Hydroxyapatite" target="_blank">Hydroxyapatite</a> (HA), a calcium phosphate mineral that is a major component of natural bone. Some formulations may also include other bioactive materials.

• Structure: It possesses a porous structure that allows for <a href="https://www.wikiwhat.page/kavramlar/Bone%20In-growth" target="_blank">Bone In-growth</a> and vascularization. This porosity is crucial for providing space for cells to migrate into the graft and for blood vessels to supply nutrients and oxygen.

• Bioactivity: Pronebone is designed to be bioactive, meaning it interacts with the surrounding bone tissue to promote bone formation. The HA component facilitates the attachment and proliferation of bone-forming cells (osteoblasts).

• Applications: Pronebone is used in various orthopedic procedures, including:

  • Filling bone defects caused by trauma or disease.
  • Spinal fusion.
  • Joint reconstruction.
  • Dental applications, such as ridge augmentation and socket preservation after tooth extraction.

• Advantages: Compared to autografts (bone harvested from the patient) and allografts (bone harvested from a donor), Pronebone offers several potential advantages:

  • Eliminates the need for a second surgical site for autograft harvesting, reducing pain and morbidity.
  • Reduces the risk of disease transmission associated with allografts.
  • Provides a consistent and readily available source of bone graft material.
  • Demonstrates good biocompatibility and osteoconductivity.

• Osteoconductivity: <a href="https://www.wikiwhat.page/kavramlar/Osteoconductivity" target="_blank">Osteoconductivity</a> refers to the ability of a material to provide a scaffold for bone growth. Pronebone's porous structure and HA composition make it highly osteoconductive, guiding bone formation along its surface.

• Resorption: The rate of resorption, or breakdown, of Pronebone varies depending on the specific formulation and the rate of new bone formation. Ideally, the graft resorbs at a rate that matches the rate of new bone growth, ensuring that the defect is gradually replaced by natural bone.

• Forms: Pronebone is available in various forms, including granules, blocks, and putties, to suit different surgical needs and defect sizes.