What is cd3?

CD3 is a complex of proteins found on the surface of T cells and some natural killer (NK) cells. It is involved in signal transduction pathways that activate T cells and facilitate communication between T cells and antigen-presenting cells (APCs). CD3 is composed of five different polypeptide chains, known as CD3 gamma, CD3 delta, CD3 epsilon, CD3 zeta, and T-cell receptor (TCR) associated protein-70 (ZAP-70). The CD3 complex is critical for the function of T cells, and mutations in the CD3 genes have been associated with some cases of immunodeficiency disorders. Therapies targeting CD3 are being developed for the treatment of certain autoimmune diseases and cancer.