What is cd64?

CD64, also known as Fc-gamma receptor I, is a cell surface protein that plays a key role in the immune response. It is a high-affinity receptor for the Fc portion of immunoglobulin G (IgG) antibodies and is primarily found on the surface of monocytes, macrophages, and neutrophils.

CD64 plays a crucial role in mediating antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis, as it allows these immune cells to recognize and bind to IgG-coated pathogens or cells. This triggers a series of immune responses, leading to the destruction or clearance of the foreign invaders.

CD64 is also involved in the regulation of inflammatory responses and cytokine production. Dysregulation of CD64 expression or function has been linked to various autoimmune diseases, inflammatory disorders, and infectious diseases.

CD64 is commonly used as a marker for identifying and studying monocytes, macrophages, and neutrophils in research and clinical settings. It can be detected using flow cytometry and immunohistochemistry techniques. Additionally, CD64-targeted therapies are being developed for the treatment of certain immune-related disorders.