Gyrate is a rare genetic disorder that affects the metabolism of amino acids. It is caused by a deficiency of the enzyme ornithine ketoacid transaminase (OKT), which is involved in the breakdown of the amino acid, ornithine.
As a result of this deficiency, ornithine and its byproducts build up in the body and cause damage to tissues and organs, particularly the eyes and kidneys. Symptoms may include vision loss, kidney disease, muscle weakness, and intellectual disability.
The condition is inherited in an autosomal recessive pattern, which means that a person must inherit two copies of the defective gene (one from each parent) to develop the disorder.
Treatment of gyrate involves strict dietary restrictions and supplementation with vitamin B6 to help manage symptoms and slow disease progression. However, there is currently no cure for the condition.
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